منابع مشابه
Brain serotonin-2 receptors in acute mania.
BACKGROUND Although 5-hydroxytryptamine (5-HT) has been implicated in mania, the precise alterations in the 5-HT system remain elusive. AIMS To assess brain 5-HT2 receptors in drug-free individuals experiencing a manic episode in comparison with healthy volunteers using positron emission tomography (PET). METHOD Participants (n = 10) with DSM-IV bipolar I disorder-manic episode and healthy ...
متن کاملInduction of mania with serotonin reuptake inhibitors.
Serotonin reuptake inhibitors (SRIs) are now considered the first-line treatment for depression, but they have not been well studied in bipolar disorder. Recently, some authors have recommended that patients at risk for antidepressant-induced mania be treated with SRIs rather than tricyclic antidepressants (TCAs). Clinical information about 11 patients who developed mania during treatment with ...
متن کاملInteraction of SM-3997 with serotonin receptors in rat brain.
The propensity of SM-3997 to displace 3H-ligands was tested in vitro in a number of receptor-binding assays. SM-3997 possessed a high affinity towards 5-HT1A receptors, low affinity towards dopamine (D2) and 5-HT2 receptors, and no affinity towards benzodiazepine (BZ), GABA, 5-HT1B and adrenergic receptors. Moreover, SM-3997 facilitated neither 3H-flunitrazepam binding nor 3H-muscimol binding. ...
متن کاملSerotonin 5-HT2C Receptors: Chemical Neuronatomy in the Mammalian Brain
Serotonin 5-HT 2C receptors belong to the 5-HT 2 family, which includes 5-HT 2A and 5-HT 2B receptors. All three share similarities in their molecular structure, pharmacology, and signal transduction pathways (Barnes and Sharp 1999; Hoyer et al. 1994). Initially named 5-HT 1C, based on the conventions for naming serotonin receptors at the time of its discovery, it was later renamed 5-HT 2C rece...
متن کاملModulation by estradiol of serotonin receptors in brain.
Estrogens were found to exert a biphasic effect on the density of serotonin receptors in the female rat brain: an acute reduction in serotonin receptor density throughout the brain is followed 48 to 72 hr later by a selective increase in those brain regions known to contain estrogen receptors--hypothalamus, preoptic area, and amygdala. The acute reduction in serotonin receptor density can be mi...
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ژورنال
عنوان ژورنال: British Journal of Psychiatry
سال: 2010
ISSN: 0007-1250,1472-1465
DOI: 10.1192/bjp.bp.108.057919